Optical techniques for cervical neoplasia detection

• Tatiana Novikova

Beilstein J. Nanotechnol. 2017, 8, 1844–1862, doi:10.3762/bjnano.8.186

• technique for the identification of precancerous lesions, confined to the epithelium (cervical intraepithelial neoplasia) still remains a challenging problem. It is known that even at early stages the neoplastic transformations of cervical tissue induce complex changes and modify both structural and

• , photoacoustic imaging), probe different tissue properties that may serve as optical biomarkers for diagnosis. Both the advantages and drawbacks of these techniques for the diagnosis of cervical precancerous lesions are discussed and compared. Keywords: cervical intraepithelial neoplasia; confocal

• tissue architecture, namely, on the thickness of the involved epithelium layer (Figure 2). When one third of the epithelium is affected by disorganized growth and cytological atypia we talk about mild dysplasia or cervical intraepithelial neoplasia (CIN) of 1st grade (CIN 1). Such abnormality can regress